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Rats in group 1 received ip injections of (14)C Disodium EDTA, group 2 received this compound on depilated skin, rats in group 3 received this compound on depilated and abraded skin (abraded every 2 or 3 cm over treated area), and group 4 was the control group

And some 60,000 youths aged 12-17 were using them as well (though that data is a bit old and wed wager its far more by now)

Data availability The RNA-seq data generated in this study has been deposited in the Gene Expression Omnibus (GEO) database at NCBI under accession code GSE249592

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Acetoacetate and beta-hydroxybutyrate are excreted through the kidneys into urine, while acetone is primarily eliminated through respiration (causing characteristic "fruity" breath)