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While tirzepatide reduces appetite and calorie intake, L-carnitine theoretically optimizes fat oxidation during the calorie deficit that results

reductions in steatosis, lobular inflammation, and ballooning

doi:10.1152/ajpcell.1996.271.4.C1380 50

Back Larsen, PJ, Fledelius, C, Knudsen, LB, Tang-Christensen, M (1 Nov 2001) 'Systemic administration of the long-acting GLP-1 derivative NN2211 induces lasting and reversible weight loss in both normal and obese rats', Diabetes , 50/11, 253039

West MB, Hill BG, Xuan YT, Bhatnagar A

Topiramate contributes paresthesia (tingling in hands and feet), taste changes (especially carbonated beverages tasting flat or metallic), cognitive slowing, word-finding difficulty, and kidney stone risk