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DIV-1 is required for GLP-1/Notch-mediated germline proliferation To further explore the requirement of S phase progression in GLP-1/Notch-mediated early germline proliferation, we depleted the expression of genes, encoding Cyclins (Group 1), DNA replication processing proteins (Group 2), and DNA replication licensing proteins (Group 3) by feeding RNAi of glp-1(bn18) mutants (Fig

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Changes in the phosphoproteome depend on functional selectivity and location bias In light of the location bias that was observed for the small molecule relative to peptide agonists of GLP-1R, we sought to examine the functional consequences of differences in intracellular signal transduction by phosphoproteomics

Middle East Fertil Soc J