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This first and conceptual important study on DPP-4 inhibition in subjects with type 2 diabetes was presented at the American Diabetes Association (ADA) meeting in Philadelphia in 2001 (Figure 3 shows the main data of this study: the reduction in 24-hr glucose levels after treatment with NVP DPP728 in relation to the unchanged level after placebo, and the reduction in HbA1c already after 4 weeks therapy

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Numerous genes related to syndromic monogenic, non-syndromic monogenic, oligogenic, and polygenic obesity have been found in attempts to understand the genetic basis of obesity [7]

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Insulinotropic toxins as molecular probes for analysis of glucagon-likepeptide-1 receptor-mediated signal transduction in pancreatic beta-cells