Recently, we reported that an environmental metabolite extracted from Streptomyces venezuelae increases ROS and damages mitochondria, leading to eventual neurodegeneration of C
Metabolic syndrome and risk factors for non-alcoholic fatty liver disease
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It acts primarily at the injury site: it upregulates growth hormone receptor expression locally, drives angiogenesis via VEGF, activates the nitric oxide system, and switches on the CREB pathway, the cellular trigger for repair gene expression
Cancer Res 67(24):11687-11695, 2007