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It also considerably increased the risk of pulmonary hypertension, and around 20 percent of those who took Phen-Fen needed surgery to repair damaged heart valves

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However, there is still no definitive evidence of amyloid- toxicity, and many mechanisms behind the accumulation of plaques and tangles remain unknown [111]

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Immobilon-PVDF membranes (Millipore, USA) was used for immunoblotting

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