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For most modern GH research, Ipamorelin's selectivity makes it the preferred GHRP, typically combined with CJC-1295 for synergistic effects
The Hostynek and Maibach group at UCSF measured exactly this in 2011: human skin permeation of GHK-Cu as a function of skin layer, with the result that the peptide accumulates in the upper stratum corneum but does not pass through to viable epidermis or dermis in any meaningful quantity 4
However, formulations can differ significantly
If a clinician chooses to employ GHK-Cu, record justification and begin at a low level
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