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doi: 10.1128/mbio.00632-19 20 HickmanR.DOliveiraT.DaviesA.ShergillS
Sphingosine-1-phosphate (S1P), by inhibiting MMPs and promoting glycocalyx synthesis, has shown protective effects in preclinical models
same drug, different label) If you have moderate obesity (BMI 30 to 35): Semaglutide (Ozempic for diabetes, Wegovy for obesity) or liraglutide (Victoza for diabetes, Saxenda for obesity) If you want the simplest regimen: Once-weekly semaglutide or tirzepatide Goal: Minimize injection frequency Once weekly: Semaglutide, tirzepatide, dulaglutide, efpeglenatide, retatrutide Every two weeks (pipeline): Ecnoglutide (pending approval) Oral (no injections): Semaglutide (Rybelsus) or orforglipron (Orfoglip) Goal: Minimize gastrointestinal side effects Lower nausea profile: Tirzepatide (dual agonist
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American society of clinical oncology recommendations for the initial hormonal management of androgen-sensitive metastatic, recurrent, or progressive prostate cancer
Interestingly, the clinical manifestations of the disorder can be improved by supplementation of high doses of carnitine
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