Pigmentation has multiple causes and the most effective treatment depends entirely on correctly identifying which is driving your concern
Nature 418:191195 Schena M, Heller RA, Theriault TP, Konrad K, Lachenmeier E, Davis RW (1998) Microarrays: biotechnologys discovery platform for functional genomics
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GPX4 knockdown keratinocytes appeared to have a decreased capacity for cell adhesion, along with accumulating lipid peroxides and enhanced levels of various pro-inflammatory elements, including COX-2, 4-HNE, and prostaglandins (Sengupta et al., 2013)
Redox modifications of proteins of the mitochondrial fusion and fission machinery