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Mesna is widely used as a systemic protective agent against chemotherapy toxicity

J Am Diet Assoc 2004 104(12):1836 - 1845 J

Since fatty foods may feel heavy for some people, start with a modest serving and see how you feel

Patients should be reassured that experiencing some digestive discomfort does not necessarily mean they must discontinue treatment, as there are effective management strategies available

Rushing the schedule increases the risk of nausea, vomiting, and other gastrointestinal side effects

SURMOUNT-4 (PMID 38078870) used a withdrawal design adults stabilised on tirzepatide were re-randomised to continue or switch to placebo