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Cell 9 , 29052916 (1998)
For example, a study on semaglutide showed that participants lost an average of 15% of their body weight over 68 weeks
All the values were presented as mean SEM
These effects are blunted by vagotomy or pharmacological GLP-1R blockade, and by genetic inactivation of GLP-1R signaling in whole body or selectively in vagal afferents
This multi-target mechanism has made it a compound of significant interest in metabolic research, particularly in studies exploring energy homeostasis, multi-receptor signalling, and metabolic flexibility
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