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In the palmitic acid (PA)-induced ceramide synthase 6 (CERS6)-deficient HK-2 and CERS6 knockdown db/db mouse models, aggravation of DKD symptoms and renal interstitial fibrosis were found, possibly due to the interaction of CERS6-derived ceramide with PINK1 to inhibit PINK1/Parkin-mediated mitophagy, which aggravates DKD [118]

Stewart A, et al

doi: 10.1016/j.immuni.2020.08.012 74 GuanBTongJHaoHYangZChenKXuHet al

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A generic must show it is bioequivalent to the branded product before a regulator approves it

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