off-label use of glp-1 agonists for obesity in 2016 Genetics: How Genes Affect Appetite, Semaglutide, and Tirzepatide Response Prevalence of use and interest

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Its concurrent engagement of GLP-1R, GIPR, and GCGR distinguishes it structurally and pharmacologically from both selective GLP-1R agonists such as semaglutide and dual GLP-1R/GIPR agonists such as tirzepatide

However, there is currently very little direct evidence on this (further discussion here)

Eder, W

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Additionally, there are indirect factors influencing TJs, such as matrix metalloproteinases (MMPs), NO, ROS, Rho-associated protein kinase (ROCK), and NF-B signaling pathways [120,121,122,123,124]