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Description

In the next series of slides, we will consider the history and physical exam.

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Clinical trials included participants up to age 75 with no significant safety concerns in older adults

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Some mitochondrial abnormalities have also been found in other forms of NBIA

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Most protocols call for morning dosing, though the evidence for timing specificity is thin

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There is a great deal of phenotypic variability in patients with type 3 Bartter syndrome ranging from potentially lethal dehydration and hypotension during the first year of life to polyuria, hypocalciuria and hypomagnesemia later in life that resembles the symptoms of Gitelman syndrome

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