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For instance, a study published in the New England Journal of Medicine found that participants taking semaglutide lost an average of 15% of their body weight over 68 weeks compared to those on a placebo

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One pharmacokinetic study showed a modest bioavailability of only 0.8 percent for oral semaglutide, meaning less than one percent of the drug is absorbed into the blood where it can take effect

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Risk is higher with heart disease or its risk factors

The key distinction is that your prescription must document a medical conditionsuch as obesity, type 2 diabetes, or cardiovascular risk factorsrather than cosmetic weight reduction alone