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Nat Med 24(5):551555 Clement K, van den Akker E, Argente J, Bahm A, Chung WK, Connors H et al (2020) Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials