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In chronic liver diseases, c-Met expression is increased to promote hepatocyte proliferation and inhibit inflammation

Lammert F, Gurusamy K, Ko CW, Miquel JF, Mendez-Sanchez N, Portincasa P, van Erpecum KJ, van Laarhoven CJ, Wang DQ (2016) Gallstones

This unwanted effect doesn't occur often, but it can be unpleasant for patients, especially if they use the peptide for accelerated fat loss, because then they will find it particularly hard to cope with the reduced mobility and swollen appearance

In clinical trials, nausea affected roughly 20 percent of participants in the early weeks

This route offers potential for future oral or transdermal formulations, but more research is needed before real-world use