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For instance, curcumin inhibits TNF-alpha release from glial cells
Furthermore, the absence of standardized formulations complicates dose uniformity and treatment reproducibility, as differences in concentration, excipients, or stability across preparations can materially influence therapeutic efficacy and safety outcomes
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The dissociation of the complexes leads to ASK1 activation and prolonged activation of P38 and JNK that cause cell growth arrest by increasing the expression of the CDK inhibitor P21 CIP1 and apoptosis
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