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Due to differences in mechanisms, dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonists were not included in the definition of GLP-1 RAs users in this study [35,36,37]
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After over a year of use, many patients lost between 15% and 20% of their body weight
The test examines pathways involving GIPR rs1800437, FTO rs9939609, and MC4R rs17782313variants known to affect appetite regulation and weight loss outcomes
Many with -thalassemia achieved transfusion independence, while those with SCD experienced complete resolution of vaso-occlusive episodes
However, a pattern of dramatically improved glucose, A1c, lipids, and liver enzymes combined with significant weight loss may raise clinical suspicion that a GLP-1 receptor agonist or similar metabolic medication is being used
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