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Tumor angiogenesis, the formation of blood vessels that feed malignant growths, is a recognized hallmark of cancer progression, and any compound upregulating VEGF or related angiogenic mediators carries a theoretical association with the process

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This is contrast to previous findings of acute MC4R peripheral administration leading to changes in social behavior as previously described by Penagarikano et al

doi:10.1016/j.hrtlng.2016.12.004 [23] Origuchi T, Migita K, Nakashima T, Honda S, Yamasaki S, Hida A, et al

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