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Excessive activation of Notch signaling in macrophages promote kidney inflammation, fibrosis, and necroptosis
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2021;118(17):e2019474118
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Instead of starting at the full 2.5 mg weekly dose, microdosing protocols use sub-therapeutic amounts, typically between 0.5 mg and 1.5 mg, administered weekly or even split into multiple smaller injections per week
Meal size and timing adjust naturally for most patients
