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A positive test result (Phe greater than 150 mol/L) prompts the physician to begin a phenylalanine-restricted formula and requires a confirmatory quantitative Phe level

Hyperinsulinemia enhances ovarian theca cell androgen production and increases free IGF-1 activity, while elevated androgens exacerbate visceral adiposity and impair insulin signaling in metabolic tissues [81, 82]

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5) They can increase hair growth and potentially affect the follicle size