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While all GLP-1RAs activate the same receptor, they differ in their structures (e.g., semaglutide has 94% homology to native GLP-1 with specific amino acid substitutions and fatty acid side chain allowing albumin binding) and half-life (~ 1 week for semaglutide, five days for dulaglutide, and 13 hours for liraglutide)

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Any excess gets excreted in the urine