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Average fat mass reduction across reviewed trials was under 1% compared to lifestyle advice alone

66 CounoupasCFerrellKCAshhurstABhattacharyyaNDNagalingamGStewartELet al

Data from clinical studies have also shown that renal impairment in patients with overweight or obesity does not impact the pharmacokinetics of tirzepatide [see Use in Specific Populations (8.6)]

The titration protocol (starting at 2 mg and increasing every four weeks) is essential for tolerability

408 A controlled trial in 252 participants with major depression compared standard of care plus 2,000 mg NAC daily with standard of care plus placebo

Folic acid deficiency is treated with tablets in addition to a folate-rich diet