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During the detoxification process, GSTs, which represent the most important classes of conjugating enzymes, conjugate phase I-activated molecules (or toxic molecules that are already activated) with GSH
The specific involvement of TGR5 in GLP-1 and PYY release in response to OA was examined using TGR5 specific siRNA
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3a) in addition to superfusing it with extracellular fluid
Additionally, there are concerns about the potential teratogenic effects of GLP-1 agonistsspecifically, whether these medications could affect fetal organ development or lead to adverse outcomes such as congenital malformations or low birth weight
2 The central nervous system effects of GLP-1-RA lead to delayed gastric emptying causing earlier satiety and decreased appetite
Both are legitimate, but their evidence bases differ
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