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More recently, a large cohort study in United States veterans with type 2 diabetes reported that GLP-1 receptor agonist use was associated with lower risks of several incident substance use disorders, strengthening the translational significance of the preclinical literature [22]
For someone starting at 300 pounds, 50 pounds is about 17% of body weight, which is closer to the average result on higher-dose semaglutide and well within the average range for tirzepatide at 15mg
Theoretical interactions may occur with anticoagulants such as warfarin, though evidence is limited and patients should seek pharmacist advice and consider additional INR monitoring if co-administration is necessary
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