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The Inflation Reduction Act, which allows the US to directly negotiate drug prices with manufacturers for the first time, last month slashed the cost of 10 of the worlds biggest medicines by 38% to 79% for 2026
Mediation analysis indicated that weight loss did not attenuate the treatment effect on MACE, while changes in waist circumference accounted for approximately one-third of the cardiovascular benefit
They do not replace levothyroxine
Continuing tirzepatide long-term may be the most effective approach to maintaining weight loss
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