Semaglutide is a prescription GLP-1 receptor agonist that mimics a natural hormone involved in appetite and blood sugar control
GIP Agonism Reduces appetite, nausea, and bone resorption Increases insulin & glucagon production, and lipogenesis Glucagon Agonism Reduces appetite, food intake, and gastric emptying Increases insulin production, energy expenditure, and nausea Amylin Agonism Reduces appetite, food intake, glucagon production, and gastric emptying Increases energy expenditure Reduces bone resorption and increases bone production PYY Agonism Reduces appetite, food intake, and gastric emptying Increases energy expenditure and nausea The Cost Challenge for Payers The cost of GLP-1s continues to be a significant concern for payers between skyrocketing costs and utilization over the past several years
Neither is automatically better, because they do different jobs
doi:10.1249/MSS.0000000000001448 Volpi E, Nazemi R, Fujita S
WHO projections of mortality and burden of the disease 20042030
In theory, more body fat should mean more leptin signaling, which should prevent overeating