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The disruption of the HPG axis in PCOS and the possible beneficial effects of GLP-1 RA are depicted in Fig

Several clinical studies have also indicated that GLP-1R agonists may serve as a potential therapeutic strategy for DPN (2325)

People were still losing weight when the trial ended, meaning the final number could be even higher with longer use (Lilly Press Release, Dec 2025)

Increased core temperature: High progesterone elevates core temperature, reducing performance and slowing recovery

CD38 hydrolyzes NAD+ into nicotinamide and ADP-ribose, directly reducing the pool of NAD+ available for sirtuins and PARP-1

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