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Any excess is typically excreted in the urine, lowering the risk of toxicity

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Plasma half-life in animal studies is approximately 4 hours after subcutaneous administration

[2] For this reason, elevated serum homocysteine over 15 micromol/L and methylmalonic acid (MMA) over 0.271 micromol/L are considered better indicators of B 12 deficiency, rather than relying only on the concentration of B 12 in blood

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Furthermore, haem is believed to be more efficiently absorbed by cells than non-haem iron, and some reports indicate that haem uptake via haem transporters increases during iron deficiency 52,53