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Fourteen days after UUO, the AAV-Ctrl-injected mice presented decreased GPX4 expression and accumulation of lipid hydroperoxide (4-HNE)- and TUNEL-positive cells, as detected by immunofluorescence and TUNEL assays (Sup

Higher UFC increases the risk of Alzheimer's disease [131]

Glutathione helps maintain these tight junctions by protecting the proteins that hold them together

Collectively, these strategies demonstrate that metabolically targeting TAM subsets is a powerful approach to controlling ferroptosis, suggesting multiple avenues for combination therapies that integrate ferroptosis inducers, immune checkpoint modulators, and metabolic inhibitors

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