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Amylin acts on the area postrema (brainstem) and lateral parabrachial nucleus to reduce hedonic eatingthe reward-driven 'want to eat' circuits that operate independently of energy balance

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The pattern is that both are GI-forward drugs, but retatrutides glucagon activity adds a cardiovascular consideration (heart rate) that cagrilintides amylin mechanism does not, and the same potency that produces retatrutides larger weight loss is associated, in indirect analyses, with a heavier adverse-event load

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Muscle tears and strains Hamstring tears Calf strains Shoulder muscle injuries Promotes faster muscle fiber repair and reduces scar tissue formation