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The key difference is in dosing, as tirzepatide escalation starts at 2.5mg rather than 0.25mg, which means much larger weekly doses and faster vial consumption

After initial repletion, a maintenance dose is given, often 1,000 mcg intramuscularly every month or every 2 to 3 months, to prevent recurrence of deficiency

Still, the overlap between the published tendon literature and the real-world user dataset is not something we can ignore

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In contrast, TB-500 (Thymosin -4) functions as a G-actin sequestering molecule