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Ten human TLRs that signal via 4 adaptor proteins and 2 initial kinases activate distal kinases that subsequently regulate transcription factors such as NFB and activator protein 1 (AP-1), that control gene expression

doi:10.1016/j.dld.2007.02.006 Merat S, Khalili S, Mostajabi P, Ghorbani A, Ansari R, Malekzadeh R

While studies in mice indicate the potential direct benefits of GLP-1 on the skeletal muscle and bone, human data supporting this hypothesis are absent owing to the absence of GLP-1 receptors in the human skeletal muscle, implying that any effects on muscles are likely indirect [114]

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