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For obese or diabetic individuals, these shifts translate to a reduced risk of complications and improved daily health
Semaglutide should be avoided only if you have a personal history of medullary thyroid cancer or MEN2 syndrome
Similarly, a post-hoc analysis of SURPASS-1, enrolling 478 patients with T2D, found that all doses of tirzepatide as monotherapy increased insulin sensitivity compared to placebo, as suggested by the decreases in HOMA2-IR by 923% (vs +14.7% with placebo) and fasting insulin levels by 212% (vs +15%) and the increase in adiponectin by 1623% (vs 0.2%) and IGFBP-2 by 3870% (vs +4.1%) at 40 weeks [76]
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2025 Aug 26;68(Suppl 1):S982
* These statements have not been evaluated by the Food and Drug Administration (FDA)
