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Beyond symptom control, BAs exert beneficial metabolic effects by interrupting enterohepatic circulation, thereby triggering compensatory hepatic BAs synthesis from cholesterol and activating intestinal FXR-FGF19 signaling
doi: 10.1073/pnas.0904187106 287 BookoutALde GrootMHMOwenBMLeeSGautronLLawrenceHLet al
However, off-label prescribing for weight loss is legal when done by qualified doctors
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The 1.0 mg to 1.7 mg and 1.7 mg to 2.4 mg transitions are smaller relative increases, but cumulative GI adaptation means they usually feel less dramatic than earlier escalations
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