What the evidence supports today is biological plausibility worth a proper trial
Cell Metab 3:153165 Nauck MA, Quast DR, Wefers J, Pfeiffer AFH (2021) The evolving story of incretins (GIP and GLP-1) in metabolic and cardiovascular disease: A pathophysiological update
44 : 577585 Taglialatela G, Navarra D, Olivi A, Ramacci MT, Werrbach-Perez K, Perez-Polo JR et al
Significant Results : More substantial weight loss typically occurs after 12-16 weeks of consistent use
Heat unfolds the protein structure
Since side effects are the leading documented reason people stop, the difference between a program with responsive clinical support and one with a slow message queue is often the difference between adjusting a dose and abandoning treatment