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The effect typically improves significantly once steady state is reached around week four, as trough levels are substantially higher at that point
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doi: 10.1210/jc.2017-02006 14 NakamoriHIidaKHashitaniH
This is a normal, expected part of the titration process, not a sign that the medication is failing
And if you have questions about optimizing your semaglutide timing , small adjustments can make a measurable difference in both efficacy and tolerability
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