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This formulation utilizes three ways to support glutathioneintracellular with SAG, intracellular biosynthesis with NAC, and extra/intracellular (systemic) support with GSH
Cellular uptake was evaluated in SH-SY5Y neuroblastoma and hBMECs using confocal laser scanning microscopy and flow cytometry revealing 5.4X higher uptake of lactoferrin-conjugated nanoparticles as compared to non-conjugated PLGA NPs following 5 h of exposure
Raw peak areas were utilized for subsequent analysis and no data points were excluded
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