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The theoretical risk of accelerating the growth of a pre-existing, undiagnosed tumor (especially if administered systemically) remains the primary long-term safety concern that requires further clinical research

Meanwhile, deficiency in lipophagy exacerbates lipotoxicity (85)

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This analysis revealed a 40% reduction in the replating capacity of end-stage clonogenic surviving cells that were treated 20 days earlier with sertraline in combination with 4 Gy RT compared to DMSO control (DMSO vs Sert 4 Gy, Sert vs Sert 4 Gy, 4 Gy vs Sert 4 Gy, p = 0.0008, p = 0.0278, and p = 0.0129, respectively) (Fig

69 The important role of taurine as a cellular osmoregulator will not be described in detail in this paper