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Yes, but people with absorption issues (due to age, diet, or health conditions) may not get sufficient B12 from pills alone

For some people, especially those with certain genetic variations like the MTHFR mutation, converting cyanocobalamin can be a challenge

Viechtbauer, 2010), employing a random-effect model via the metafor R package ( 3 Results 3.1 Study selection and characteristics The search strategy identified 2,183 potential articles: 1,299 from PubMed, 353 from Scopus, 527 from Embase, 4 from manual screening

This can also affect vitamin B12 absorption

If you are in Madison, AL, B12 injections are available at Madison Integrative Medicine

Those results are in a different category of efficacy compared with B12 or many over-the-counter supplements