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Peptides like Amlexanox are also being explored for their potential in managing severe chronic pain

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management (Ozempic) and chronic weight management (Wegovy) in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with weight-related comorbidities

Cell Metab (2020) 31(1):135

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indeed, if some studies showed that the hormone is able to significantly downregulate autophagy in different disease models 63,64,65 , other reports failed to confirm those findings, providing evidence for an enhancement of the autophagic process upon melatonin treatment 66,67,68