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Although these agents produce substantial and sustained weight reduction, emerging clinical observations suggest that chronic therapy may be accompanied by changes in lean mass trajectory, reduced protein intake, and micronutrient insufficiency

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ATTAIN-MAINTAIN An innovative trial evaluating whether orforglipron can maintain weight loss previously achieved with injectable GLP-1 receptor agonists (semaglutide or tirzepatide)

These may include: Nausea Vomiting Diarrhea Constipation Bloating or gas Decreased appetite Fatigue To minimize side effects, its important to start with a lower dose and gradually increase as tolerated