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One consideration involves gastrointestinal effects

It can also speed up the browning of white adipose tissue, so theres more BAT to be burned for body heat

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doi: 10.1200/JCO.2016.67.4044 109 MunozLDSweeneyMJJamesonJM

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Primary safety considerations include ensuring product purity to prevent hexavalent chromium contamination, administering the correct dosage to minimize side effects, and providing accurate labeling regarding potential drug interactions