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Next-generation sequencing of 500 POI patients identified novel responsible monogenic and oligogenic variants

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Conclusion Our understanding of how the GI tract contributes to disease, especially the development of obesity and diabetes, is still developing

"As the science evolves, we are achieving a deeper understanding of how weight loss, and treatment with these medications, can improve outcomes across diverse patient populations with obesity." A secondary analysis of the SUMMIT trial looked at the effect of tirzepatide on cardiac structure and function in 106 patients from the main SUMMIT study with HF with preserved ejection fraction (HFpEF) and obesity