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Standard escalation protocol from clinical trials The Phase 2 trial published in the New England Journal of Medicine tested several dose groups
So you are absorbing less B12 AND eating less of it simultaneously
doi: 10.14336/AD.2024.1085 119 AbrishamdarMJalaliMSFarboodY
Also, research shows that B12 absorbs best when dissolved in an isotonic solution like saline
Pharmacy Compounding Advisory Committee Meeting Information Alliance for Pharmacy Compounding
The efficacy of any research protocol depends entirely on the purity of the compound
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