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This provides two key advantages: Protection from intestinal degradation the phospholipid bilayer shields the GSH molecule from GGT and digestive enzymes, allowing it to reach the bloodstream intact Cellular fusion the liposomal shell is composed of the same phospholipids that form cell membranes, enabling fusion with target cell membranes and direct intracellular delivery Additionally, sublingual absorption via the oral mucosa bypasses first-pass hepatic metabolism entirely, with the GSH entering systemic circulation directly from the mouth

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One of the most common modifications is hydroxylation catalysed by the cytochrome P-450-dependent mixed-function oxidase system