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Relative positioning: SLU-PP-332 is the most mechanistically promising molecule in 2024-2025 (directly targets ERRs, masters of the oxidative program, without the limitations of alternative targets like AMPK which also activates undesirable catabolic pathways)

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Medications: Berberine interacts with certain drugs, metformin especially, but also some antibiotics and blood thinners

These included erectile dysfunction, decreased libido, and orgasmic dysfunction

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A physician who knows your baseline can tell you exactly what would change the answer