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In this context, GLP-1 therapies may act less by eliminating senescent cells and more by slowing the processes that drive their accumulation over time

Open communication with a trial clinician about tolerability is therefore essential

Published 2022 Feb 24

Less severe prolapses can be pushed back inside the anus by hand, while more severe ones cannot and are more likely to be accompanied by anal bleeding

The question is whether the net effect is positive or negative, and the aggregate clinical data strongly suggests it is positive for most people