SURMOUNT-5: The head-to-head trial Published in the New England Journal of Medicine in 2025, SURMOUNT-5 was the first randomised trial to directly compare tirzepatide (Mounjaro) with semaglutide (Wegovy) at equivalent maximum doses in adults with obesity without type 2 diabetes
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This is the most significant safety concern
As documented by the FDA, practices such as taking a higher amount of the drug in a single dose, taking doses more frequently, or increasing the amount of the drug more quickly can cause serious gastrointestinal problems, including nausea, vomiting, diarrhea, and abdominal pain
These structural characteristics collectively distinguish Retatrutide from unmodified peptide sequences and support its classification within metabolic and appetitesignaling research categories